Primary lymphoma of bone (PLB) was first reported as a distinct clinical entity by Parker and Jackson in 1984 ( 1). In the absence of randomized controlled trials, RT should be considered in ES disease with cautions of second cancers in specific subsets of patients. However, RT significantly elevated the late toxicities of second malignancies in ES patients diagnosed at the age of 18–39 or those with appendicular sites of bone involvement.Ĭonclusion: This population-based analysis is the largest PB-DLBCL dataset to date and demonstrates a significant survival benefit associated with RT in early stages rather than advanced stages. With short-term follow up in SEER 18, none of the subgroups showed a significantly elevated risk of developing SPMs. In subgroup analyses, OS was improved with RT in those who had ES disease ( p < 0.001) but not in those who had AS disease ( P = 0.776). Moreover, a novel web-based prediction model was established to individualize the potential benefit from RT. PSM analysis further validated the survival advantage of RT ( P = 0.018). RT significantly improved survival both in UVA and MVA ( P < 0.001, P = 0.010, respectively). Most patients in ES (63.9%) underwent RT, whereas only 42.2% of AS patients received it. A decreasing trend was observed in the ES cohort after 2002, while the rate of RT utilization remained stable in the AS cohort over the past three decades. Results: A total of 1,320 patients were identified, including 856 with early-stage (ES) and 464 with advanced-stage (AS). We calculated the standardized incidence ratio to estimate the short- and long-term risk for second primary malignancies (SPM) from 2002 to 2016 in SEER –2016 in SEER 9. The effect of RT on overall survival (OS) using univariate (UVA) and multivariate (MVA) Cox proportional regression and propensity score matching (PSM) was assessed for the entire cohort and subgroups by stages. Methods: We included adult patients with PB-DLBCL diagnosed from 2002 to 2016 from SEER 18. We used the SEER database to compare the outcomes among adult patients treated with and without RT in rituximab era. Whether radiotherapy (RT) should be omitted in the modern treatment of PB-DLBCL is still under debate. 3Fred Hutchinson Cancer Research Center, Seattle, WA, United Statesīackground: Primary bone B-cell lymphoma (PB-DLBCL) is a rare entity for which existing data is limited.2Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Trial registration: identifier: NCT02815397.Shengling Ma 1 †, Yuanyuan Zhang 2 †, Ziying Li 1, Han Yan 1, Linghui Xia 1, Wei Shi 1,3 * and Yu Hu 1 * Trial registration: identifier: NCT02272686. Treatment intensification with RT may improve early stage DHL/THL outcomes. No differences in overall survival were observed between the treatment groups. Low-risk (R-IPI <2) DHL/THL patients treated with rituximab-based therapy had 3-year FFR rates of 11% and 71% for systemic therapy without and with RT, respectively p = .04. The median FFR for non-DHL/THL was not reached and was 33 and 22.3 months for DHL and THL, respectively p < .001. Systemic therapy without RT resulted in inferior freedom from relapse (FFR) (HR: 2.28 95% CI, 1.10–4.77 p = .02). This analysis included 183 patients profiled with fluorescent in situ hybridization (FISH) for alterations in MYC, BLC2, and/or BCL6. We investigated whether adding radiation (RT) to systemic therapy improved outcomes in early stage diffuse large B-cell lymphoma (DLBCL) patients with or without double- or triple-hit lymphoma (DHL/THL) biology.
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While these recordings are from the Period of. Listen free to Various Artists Bekannte Soldatenlieder 1 (Alte Kameraden, Wenn die Soldaten. National Socialism is a love of one's own race and a desire to preserve it. Release date 1899 Production date 2000 Title variation Soldier songs of the Austro-Hungarian army Series Tondokumente aus dem Phonogrammarchiv der Österreichischen Akademie der Wissenschaften Gesamtausgabe der Historischen Bestände 1899-1950 = The complete historical collections 1899-1950 Ser. 04 - D:\Documents\My Music\Soldatenlieder\04. Soldatenlieder Vol 1 is the first of 15 compact disc compilations, with future volumes to be listed shortly. The rest of the URL should be the path to the artifact relative to the base of the Apache distribution directory.įor example, for artifact foo-1.0.0.tar.gz contained in bar/foo, use /bar/foo/foo-1.0.0.tar.gz The download script substitutes the correct base URL for the variable. 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Please read about best practices for download pages. Note: there is some information which every project should include on the download page (e.g. If the artifact is foo-5.5.1.zip and it is located in bar/foo relative to, then the link provides the link for downloading.Īs an alternative, you can generate a direct download link using the following syntax: Pass in the relative path from the distribution root to the artifact as a parameter.Alter the page so the download link points to a.The starting point for using the generic a script is a download page in your project's standard documentation which describes the releases. A project-specific script, which in the end calls a integrated with a page created in the normal way for the project and uses the project's standard document look and feel.The project documentation links to it (rather than integrating it). 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Move them to one of the two software distribution sites:Ĭurrent public releases appear on /. ) as the KEYS, signatures, and any verification instructions for your release would be missing from the top-level script.ĭo not keep software distributions on your project's website. must not include a link to the top level a utility (e.g.For this you can include a link to the Apache documentation on verification. should have instructions on how to verify downloads.must have a link to the KEYS file for your project on the Apache distribution server.These links must use direct links to the Apache distribution server. must have a link to the checksum for the current release.(Note: the mirrors.cgi and closer.cgi scripts have been deprecated. must have at least one link to the current release.milestones, alphas, betas) in a timely fashion once the project releases the final or GA version. Remove all official pre-releases (e.g.You should remove links to older releases that you no longer support. 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The rune 2h sword is the strongest conventional 2-handed weapon available to Free players. Everything else is useless (including the highly overrated battleaxe). It can be made from 3 runite bars by players with level 99 Smithing, yielding 225 Smithing experience. The Dragon axe and Dragon sword are stronger. Rune Two-Hander Best KO weapon, although you sacrifice a shield for this. The Rune 2-handed Sword (commonly called a rune 2h or r2h) is the strongest 2-handed sword and third strongest overall melee weapon in RuneScape Classic. The rune 2h sword is the strongest conventional 2-handed weapon available to Free players. Rune Scimitar Best weapon for general training/PKing, period. It can be made from 3 runite bars by players with level 99 Smithing, yielding 225 Smithing experience. Two-handed (ook wel eens afgekort als 2h of 2-handed) betekend dat je het in 2 handen vast houdt. Made by using 4 Rune bars on an anvil with a Hammer in your inventory or toolbelt. On the other hand, it was free to play, and would run on almost any computer without an installation. It can be made using the Smithing skill at level 99 using 3 runite bars and a hammer on an anvil granting 225 Smithing experience. Runescape was slow, ugly, and idiosyncratic. It is stronger than the Adamant 2h sword, while being weaker than the Dragon 2h sword. The Rune 2-handed Sword (commonly called a rune 2h or r2h) is the strongest 2-handed sword and third strongest overall melee weapon in RuneScape Classic. The rune 2h sword is a two-handed sword that is made of rune. Taking a screenshot on Macs is as simple as pressing “shift,” “cmd,” and “3” simultaneously. You will easily access the photo from the “Photo Gallery” on the phone by doing this. Take a typical screenshot to take a screenshot of the world. On the iPhone, you can play some Minecraft versions. The picture is then saved in the “Photo Gallery” section in the “Photos” section of the phone. 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Markup Hero – Taking screenshots of Minecraft is a better alternativeĪ revolution has taken place in the world of multiplayer games thanks to Minecraft. You can check out seven amazing "Heaven" covers in the videos below. Jason Aldean & Bryan Adams Take the 2022 CMT Awards to ‘Heaven’ The duo was nominated for collaborative video of the year at the CMT Music Awards back in 2010 for their 'Heaven' performance on. Matt Bomer recently covered "Heaven" for Magic Mike XXL, while Jason Aldean and Gavin DeGraw's renditions have been making the rounds for years. However, as you'll see in the video below, she slays.Ĭlarkson isn't the only singer to successfully take on Adams' song, though. "Heaven" is a popular song to cover, so Clarkson had her work cut out for her. No matter how random the song choice (I'm looking at you, *NSYNC's "Bye Bye Bye"), the American Idol winner never fails to use her incredible vocal talent and personality to make it her own. "Heaven" certainly didn't disappoint, and it's the latest in a long line of spectacular covers by Clarkson. "I chose this one because this is my husband's, one of his favorite songs," Clarkson told the audience of her Aug. Back in 2008, Jason Aldean and Bryan Adams teamed up for an episode of CMT Crossroads, for the ultimate country/rock crossover. Bryan Adams > One We Wont Forget > She Loved Me > 1994 > Gonna Know We Were Here > Just Passing Through > Country Boys World > Just Gettin Started > Aint No Easy Way > You Make It. Jason Aldean & Bryan Adams Sing Heaven at 2022 CMT Awards Jason Aldean & Bryan Adams Sing Heaven at 2022 CMT Awards. (If you need proof, look no further than Clarkson's cover of "Blank Space" by Taylor Swift or "Stay" by Rihanna.) Naturally, when Clarkson performed "Heaven" by Bryan Adams, she more than did justice to the extremely romantic song. Jason Aldean > Big Green Tractor > Take a Little Ride > Dirt Road Anthem > Fly Over States > Hicktown > In Case You Dont Remember > Heaven feat. Known as a member of country’s elite headliners, Aldean’s past tours are nearing legendary status as he is one of the first of few acts in the genre to sell-out multiple stadiums including UGA’s Sanford Stadium, Fenway Park and Wrigley Field.Ĭontinuing success outside of the music industry, Aldean recently launched his latest collaboration, Wolf Moon Bourbon, an 80 proof bourbon that has been distilled from Midwestern grains and aged for four years offering a finish of caramel, oak and spice.By this point, Kelly Clarkson has pretty much established that any song she covers, she slays. Notably, all seven of Aldean’s previous studio albums have been certified platinum, while bolstering 15 billion streams and more than 20 million albums sold. But after all that time, he continues to hold his ground making modern albums with an old-school soul - most recently with his ninth studio album, 9, which debuted at the top spot on Billboard’s Country Albums chart. Aldean’s helped bring a few out of the shadows, making the mainstream’s first contact with hard rock (“Hicktown”), hip-hop (“Dirt Road Anthem”) and R&B (“Burnin’ It Down”). The exclusive purchase also includes the ability to watch Aldean’s 90-minute set for 24 hours after the show.Īfter almost 15 years at the top of his format, the three-time ACM “Entertainer of the Year” has seen trends come and go. Both shows are sold out, but tomorrow’s (May 15th) show will be livestreamed via Veeps. This weekend, Aldean returns to the stage with two headlining performances of Jason Aldean: Live at The Bonnaroo Farm in Manchester, TN. It’s been almost 10 years since Jason Aldean and Bryan Adams performed together on CMT Crossroads. |
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